Anti-EIF2S1 Antibody [Assigned #A9905]

This mouse monoclonal antibody from Antibodies.com recognizes EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha), a widely studied regulator of translational control and the integrated stress response. EIF2S1 directs GTP-dependent delivery of initiator methionyl-tRNA to the ribosome, and its phosphorylation at Ser51 by kinases such as PERK, GCN2, HRI, and PKR attenuates global protein synthesis while selectively translating stress-responsive transcripts. Researchers use unconjugated IgG reagents against EIF2S1 to monitor translation inhibition kinetics in cell-based stress models and to probe downstream signaling in unfolded protein response studies. The clone is supplied in a 100 µl volume and has been validated for western blotting, immunofluorescence, and immunoprecipitation workflows. It shows reactivity with human, mouse, and rat samples, making it useful for comparative studies in cultured mammalian cells and tissue lysates. Isotype controls and matched secondary reagents support reproducible detection across these platforms.