Anti-eIF2B beta Antibody

The polyclonal rabbit antibody from Antibodies.com targets eukaryotic translation initiation factor 2B beta (EIF2B2), supplied as 100 µl of unconjugated antiserum validated for western blot and immunohistochemistry on human samples. EIF2B2 is the catalytic beta subunit of the eIF2B guanine nucleotide exchange factor complex that regenerates eIF2-GTP to restart translation initiation, and mutations in this subunit are linked to childhood-onset leukoencephalopathy with vanishing white matter (CACH/VWM disease), making the reagent useful for studies of integrated stress response, myelin biology, and translational control in neuronal and glial cell models.

For best stability, the vial should be stored aliquoted and frozen, with avoidance of repeated freeze-thaw cycles to preserve polyclonal activity across multiple experiments. The unconjugated format lets the antibody be paired with HRP, biotin, or fluorescent secondary reagents, supporting chromogenic western blot imaging or fluorescent IHC detection on fixed tissue. Intended for research use only.