Anti-EIF2AK4 Antibody

Raised in rabbit, this polyclonal antibody from Antibodies.com recognizes EIF2AK4, the serine/threonine kinase also known as GCN2 that phosphorylates eukaryotic initiation factor 2α at Ser51 and acts as a central effector of the integrated stress response. The unconjugated reagent is supplied at 1 mg/ml in a 100 µl volume containing PBS with 0.1% sodium azide and 50% glycerol as cryoprotectant, and is intended for research use only. It has been validated for western blot, immunohistochemistry, and immunofluorescence on human and rat samples, supporting studies of amino acid starvation, uncharged tRNA accumulation, ribosome collisions, oxidative stress, and broader translational control. Researchers can use this reagent to monitor endogenous GCN2 protein levels in cell or tissue lysates by western blot and to localize the kinase in fixed cells and tissue sections via IF or IHC.