Anti-EIF2AK3 Antibody

The PERK kinase, encoded by the EIF2AK3 gene, is a transmembrane endoplasmic reticulum sensor that phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2α) during the unfolded protein response. This polyclonal reagent from Antibodies.com is raised in rabbit and supplied as an unconjugated preparation in a 100 µl volume, suitable for both Western blot and immunohistochemistry workflows on human tissue and cell samples. PERK activation is widely studied in models of ER stress, glucose metabolism, pancreatic beta-cell dysfunction, and the rare autosomal recessive Wolcott-Rallinson syndrome, where loss-of-function mutations disrupt normal stress signaling. Researchers investigating apoptosis pathways, oxidative stress, diabetes mechanisms, and neurodegenerative protein-misfolding responses rely on validated antibodies to monitor PERK expression and activation status. The reagent recognizes the native human target and supports chromogenic or fluorescent detection strategies depending on the secondary antibody chosen. Storage recommendations and detailed validation data for Western blot and immunohistochemistry applications are provided with the product documentation.