Anti-EIF2AK2 (phospho T451) Antibody

Phosphorylation of EIF2AK2 (also called PKR, Protein Kinase R) at threonine 451 sits within the kinase activation loop and is required for full enzymatic activity against eukaryotic translation initiation factor 2 alpha. Antibodies.com offers a rabbit polyclonal reagent raised against this specific phosphorylated epitope, enabling selective detection of the activated kinase in fixed tissue samples.

As an interferon-induced serine/threonine kinase, EIF2AK2 couples cytosolic dsRNA, viral infection, and other cellular stresses to translational shutdown, apoptosis, and innate immune signaling. Reagents that distinguish the phospho-T451 state from total PKR expression help separate basal expression from actively signaling pools in immunohistochemistry workflows.

This unconjugated IgG reagent from Antibodies.com is supplied as 200 µl of liquid and validated on human tissue. Intended for research use only, the antibody supports studies of viral defense pathways, integrated stress responses, and inflammation-related signaling cascades in formalin-fixed paraffin-embedded sections.