Anti-EIF2AK2 (phospho T451) Antibody

This rabbit polyclonal antibody specifically recognizes EIF2AK2 (also known as PKR, Protein Kinase R) when phosphorylated at threonine 451 within the kinase activation loop. EIF2AK2 is an interferon-induced serine/threonine kinase central to the cellular antiviral response and to translational control during cellular stress.

Validated for immunohistochemistry (IHC) on human tissue specimens, this reagent is supplied by Antibodies.com as a 100 µL volume in an unconjugated IgG format, ready for use with secondary detection systems chosen by the researcher. It enables selective detection of the phosphorylated, catalytically competent form of the enzyme and discrimination from total EIF2AK2 levels in fixed tissue sections, supporting studies of viral defense signaling, interferon response pathways, dsRNA-triggered kinase activation, and translation initiation control.

Storage should follow standard polyclonal IgG handling: refrigerated short-term storage and aliquoting are recommended to limit repeated freeze-thaw cycles. The antibody is intended for research use only and has not been validated for diagnostic or therapeutic applications.