Anti-eIF2a (Ab-51) Antibody

Phosphorylation of eukaryotic translation initiation factor 2 alpha at Serine 51 is a hallmark of the integrated stress response, and this polyclonal antibody from Antibodies.com was raised in rabbit to specifically detect that modified form of eIF2α. The kinases PERK, GCN2, HRI, and PKR install this modification during endoplasmic reticulum stress, amino acid deprivation, oxidative challenge, and viral infection, making the reagent a broadly deployed marker for translational control studies. Supplied as 100 µL of unconjugated antiserum, the antibody is validated for Western blot, immunohistochemistry, and immunofluorescence on human, mouse, and rat samples, supporting research into unfolded protein response signaling, stress granule biogenesis, and apoptosis pathways. Investigators use it in cell culture and in vivo models to monitor PERK pathway activation, link translational repression to neurodegeneration or metabolic dysfunction, and confirm pharmacologic interventions aimed at eIF2α kinases. The polyclonal format enables recognition of multiple epitopes surrounding phospho-Ser51, increasing robustness across varied sample preparations while preserving specificity for the post-translationally modified target.