Anti-eIF2α Antibody

Raised in rabbit against the eukaryotic translation initiation factor 2 alpha (eIF2α) subunit, this unconjugated polyclonal antibody from Antibodies.com targets a regulatory protein central to translation initiation and the integrated stress response. Phosphorylation of eIF2α at Serine 51 attenuates global protein synthesis while selectively translating stress-responsive mRNAs, linking the antigen to ER stress signaling, viral infection biology, and neurodegeneration research.

Validated for Western blot, immunohistochemistry, and ELISA, the reagent detects endogenous eIF2α in human, mouse, rat, and monkey samples, covering both cell-line and tissue-based workflows. Supplied as a 100 µl aliquot of unconjugated sera, it is suited to indirect detection with HRP- or fluorophore-tagged secondary reagents, and integrates with phospho-specific studies of the PERK, GCN2, HRI, and PKR kinase pathways.