Anti-EGFR (phospho Y869) Antibody

Raised in rabbit against a phosphorylated peptide surrounding tyrosine 869 of the human EGFR sequence, this polyclonal IgG reagent from Antibodies.com selectively recognizes the Epidermal Growth Factor Receptor only when that residue is phosphorylated, allowing researchers to monitor receptor activation rather than total expression levels. Phosphorylation at Y869 lies within the intracellular domain and contributes to downstream signal propagation through pathways such as Ras-MAPK and PI3K-Akt, so a phospho-specific reagent is widely used in studies of growth factor signaling, oncogenic transformation, and ligand-driven receptor downregulation.

Provided as 50 µl of unconjugated antibody in a vial, the reagent is validated for Western blot on human samples and is supplied as a polyclonal IgG with no fluorophore or enzyme attached, suitable for downstream detection chemistries of the user's choice. For best results, store at -20 ¼ in single-use aliquots to preserve activity and limit freeze-thaw cycles, and keep on ice during handling to protect from light. Intended for research use only.