Anti-EGFR (phospho T693) Antibody

Targeting a single phosphorylation mark on the EGFR receptor, this unconjugated polyclonal reagent from Antibodies.com recognizes threonine 693 only when that residue is phosphorylated. Threonine 693 sits within the intracellular domain and its modification is associated with ligand-driven receptor regulation and downstream signaling through MAPK and PI3K pathways, making the antibody a useful tool for studies of receptor activation kinetics rather than expression levels. Supplied as 200 µl of stock, the antibody is validated for Western blot detection in human cell lysates and tumor-derived samples. It is most commonly deployed in time-course or stimulation experiments that ask whether EGFR signaling is changing in response to EGF, TGF-alpha, or kinase inhibitor treatment, and is often paired with total EGFR antibodies as well as phospho-ERK and phospho-AKT readouts in cancer cell signaling research. Host species is rabbit, isotype IgG, and the product is intended for research use only. Aliquoting upon receipt is recommended to limit freeze-thaw cycles and preserve antibody activity over the shelf life.