Anti-EFEMP2 Antibody

This rabbit polyclonal antibody targets human and mouse EFEMP2 (Fibulin-4), a calcium-binding extracellular matrix glycoprotein required for proper elastic fiber assembly in connective tissues. The unconjugated antibody is supplied as 100 µl of serum-derived reagent and has been validated for Western blot, immunohistochemistry, and immunofluorescence workflows.

Researchers studying connective tissue disorders such as autosomal recessive cutis laxa type 1B, vascular smooth muscle differentiation, and elastic fiber biogenesis rely on EFEMP2-specific detection in cultured fibroblasts and tissue sections. The polyclonal format provides broader epitope coverage than monoclonal alternatives, supporting detection of full-length Fibulin-4 as well as processed forms encountered in cell lysates and conditioned media.

Endogenous expression profiling in murine embryonic fibroblasts and human dermal sections shows strong pericellular and extracellular matrix-associated staining. Store aliquots at -20 °C to preserve activity across multiple freeze-thaw cycles. This reagent is supplied by Antibodies.com for research use only.