Anti-EDNRA Antibody

The Antibodies.com reagent targets Endothelin Receptor Type A (EDNRA), a G-protein coupled receptor that mediates potent vasoconstriction through high-affinity binding of endothelin-1, endothelin-2, and endothelin-3 ligands. This rabbit polyclonal antibody is supplied as 100 µl of unconjugated antiserum and is validated for Western blot and immunohistochemistry on human specimens. EDNRA is abundantly expressed in vascular smooth muscle cells, cardiomyocytes, glomerular mesangial cells, and discrete neuronal populations, supporting investigations into cardiovascular remodeling, pulmonary arterial hypertension, and chronic kidney disease. The polyclonal format offers recognition of multiple epitopes across the receptor, which improves signal consistency across denatured and native sample preparations. Researchers characterizing endothelin signaling cascades, receptor pharmacology under disease models, or downstream calcium mobilization pathways can apply this reagent to map tissue-level distribution and semi-quantitative expression changes in cell culture lysates and paraffin-embedded tissue sections.