Anti-EDG-2 Antibody

EDG-2, also known as LPA1 (lysophosphatidic acid receptor 1, encoded by the LPAR1 gene), is a G protein-coupled receptor that mediates cellular responses to lysophosphatidic acid (LPA), a bioactive lipid signal implicated in proliferation, migration, survival, and cytoskeletal remodeling. This unconjugated Rabbit polyclonal reagent from Antibodies.com is raised against EDG-2 and validated for western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), and ELISA applications on Human and Rat samples. Investigators probing cancer cell invasion, idiopathic pulmonary fibrosis, neuropathic pain signaling, vascular development, and reproductive biology routinely map LPA1 distribution across tissue sections and cell lysates to clarify how receptor abundance shifts in disease states. Supplied as 100 µL of polyclonal antiserum, the antibody accommodates both paraffin-embedded IHC workflows and standard immunoblotting of membrane-enriched fractions, where the receptor's seven-transmembrane architecture produces characteristic banding patterns. The unconjugated format permits downstream conjugation with HRP, biotin, or fluorophores of choice, supporting flexible assay design in laboratories studying lipid-mediated signaling, tumor progression, fibrotic disease models, and central nervous system research.