Anti-ECM1 Antibody

Antibodies.com offers a rabbit polyclonal reagent raised against ECM1 (Extracellular Matrix Protein 1), a secreted glycoprotein that has become a focal point in dermatology, bone biology, and tumor microenvironment research. The unconjugated IgG is supplied as 50 µl per vial and is validated for western blot and immunohistochemistry on human, mouse, and rat samples, supporting both chromogenic and chemiluminescent detection workflows.

Loss-of-function mutations in the ECM1 gene are causally linked to lipoid proteinosis, a rare cutaneous disorder characterized by hyaline deposits in skin and mucosa, while elevated ECM1 expression has been documented in breast, thyroid, and hepatocellular carcinomas. These dual biological roles make the antibody a useful probe for comparison studies between normal and diseased tissue, including formalin-fixed paraffin-embedded sections and cell or tissue lysates. As a rabbit host reagent, it delivers robust signal generation across routine immunodetection protocols used in connective tissue and tumor marker investigations.