Anti-ECE1 Antibody

ECE1 (Endothelin-Converting Enzyme 1) is a zinc-dependent membrane-bound metalloprotease that cleaves big endothelin-1 into the vasoactive peptide endothelin-1, regulating vasoconstriction and vascular tone. This unconjugated rabbit polyclonal antibody from Antibodies.com is supplied as a 100 µl volume and validated for western blot and immunohistochemistry applications. The reagent detects endogenous ECE1 in human, mouse, and rat samples, supporting comparative studies of cardiac, vascular, and neural crest tissue. Recommended handling includes brief centrifugation before use, storage refrigerated in single-use aliquots, and limiting repeated freeze-thaw cycles to preserve antibody activity. The polyclonal format enables recognition of multiple epitopes across the ECE1 protein, providing robust signal coverage in lysate preparations and fixed tissue sections.