Anti-E-cadherin Antibody

This rabbit polyclonal reagent from Antibodies.com targets the epithelial adhesion molecule E-cadherin, also known as CDH1 or Cadherin-1, a calcium-dependent transmembrane glycoprotein of approximately 120 kDa that mediates homophilic cell-cell adhesion within epithelial adherens junctions. Raised in rabbit and supplied as an unconjugated 100 µl aliquot, the antibody is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows against human samples. In research settings, it serves as an epithelial integrity marker, supports studies of epithelial-mesenchymal transition in carcinoma progression, and aids characterization of CDH1-related hereditary diffuse gastric cancer models where E-cadherin expression is lost or reduced during invasion and metastasis.