Anti-DYNC1I2 Antibody

The DYNC1I2 gene encodes the cytoplasmic dynein 1 intermediate chain 2, a ~71 kDa core subunit of the multi-subunit dynein motor complex responsible for microtubule-directed retrograde transport of vesicles, organelles, mRNA granules, and signaling cargo in human cells. This polyclonal reagent, raised in rabbit and supplied by Antibodies.com as a 100 µl vial, is validated for Western blot and immunofluorescence workflows on human samples. In immunoblotting, the antibody produces a band consistent with the ~71 kDa intermediate chain, while immunofluorescence staining reveals the expected cytoplasmic and perinuclear distribution reflecting dynein's association with Golgi membranes, endosomes, centrosomes, and microtubule minus ends. Researchers studying motor-driven cargo trafficking, mitotic spindle assembly, viral entry pathways, and long-range axonal transport in neurons use this reagent to probe dynein complex assembly and to track changes in subunit composition under pharmacological or genetic perturbation. The unconjugated format permits flexible pairing with fluorescent, chromogenic, or chemiluminescent secondary antibodies to fit diverse detection platforms. Aliquot on receipt and store refrigerated for routine use; for longer term storage, keep frozen at -20 °C in working aliquots to limit freeze-thaw cycles and preserve antibody activity across repeated experiments.