Anti-DUSP6 Antibody

DUSP6 (Dual Specificity Phosphatase 6, also known as MKP-3) is a cytoplasmic MAPK phosphatase that selectively dephosphorylates and inactivates ERK1/2, acting as an inducible negative feedback regulator of the RAS-RAF-MEK-ERK signaling cascade. This rabbit polyclonal antibody recognizes endogenous DUSP6 and is validated for western blot and immunohistochemistry across human, mouse, and rat samples, supporting studies of MAPK pathway activity, growth factor feedback control, and the altered DUSP6 expression reported in pancreatic ductal adenocarcinoma, lung, and other solid tumor contexts.

Supplied at 100 µl as an unconjugated preparation from Antibodies.com, the reagent pairs readily with HRP- or fluorophore-conjugated secondary antibodies for chemiluminescent or fluorescence detection. For best results, aliquot upon arrival and store at -20°C; avoid repeated freeze-thaw cycles to preserve titer. Researchers working on ERK-dependent transcriptional programs, RAS-driven tumor models, or developmental MAPK signaling in rodent tissues will find this antibody applicable to both total lysate analysis by western blot and localization studies in formalin-fixed, paraffin-embedded sections.