Anti-DUSP6 Antibody

DUSP6 (Dual Specificity Phosphatase 6) is a cytosolic phosphatase that negatively regulates the ERK1/2 MAPK signaling cascade and modulates cellular proliferation, differentiation, and stress responses. This polyclonal reagent from Antibodies.com, raised in rabbit, is supplied as 100 µl of unconjugated antibody suitable for western blot, immunohistochemistry, and immunofluorescence workflows. Validated for reactivity with human and mouse samples, the reagent supports signaling studies in cancer cell lines, primary cultures, and tissue sections where altered DUSP6 expression has been linked to tumor progression and chemoresistance. Researchers commonly apply it to assess ERK pathway activity, monitor feedback responses to MEK or BRAF inhibitors, and characterize dual-specificity phosphatase expression in in vitro models. For best results, store aliquots at -20 °C in small working volumes to limit freeze-thaw cycles and protect from light to preserve binding activity.