Anti-DUSP2 Antibody

This unconjugated rabbit polyclonal antibody targets Dual Specificity Phosphatase 2 (DUSP2), a dual-specificity phosphatase that dephosphorylates both phosphotyrosine and phosphoserine/phosphothreonine residues on MAPK signaling intermediates. DUSP2, also known as PAC1, regulates innate and adaptive immune signaling and has been characterized extensively in the context of T-cell activation, macrophage polarization, and inflammatory cytokine cascades.

Distributed by Antibodies.com as a 100 µl liquid aliquot, the reagent is a polyclonal antiserum raised in rabbit and validated for Western blot (WB) and immunohistochemistry (IHC) workflows. Reactivity has been confirmed against human and mouse DUSP2, supporting translational studies that compare rodent disease models with patient-derived samples. Each vial supports research use only and is intended for laboratory scientists working on phosphatase biology, signal transduction, and immune regulation.

Common applications include probing MAPK pathway activity in activated lymphocytes, profiling phosphatase expression across tumor and matched normal tissue microarrays, tracking DUSP2 induction in chronic inflammatory disease models, and confirming expression changes following siRNA knockdown or cytokine stimulation. Because the antibody is unconjugated, it remains compatible with a broad range of secondary reporters, including HRP, alkaline phosphatase, and fluorophore conjugates, so the same lot can move between chromogenic IHC, chemiluminescent WB, and immunofluorescence imaging without additional buffer-exchange steps.