Anti-DUSP19 Antibody

This rabbit polyclonal antibody from Antibodies.com specifically recognizes Dual Specificity Phosphatase 19 (DUSP19), an intracellular phosphatase of the dual-specificity family that regulates stress-activated kinase signaling through dephosphorylation of phosphotyrosine, phosphoserine, and phosphothreonine residues on substrate proteins. Raised in rabbit hosts and supplied as 100 µL of unconjugated IgG, the reagent is validated for Western blot detection of the target in human, mouse, and rat samples.

The polyclonal format allows recognition of multiple epitopes across the DUSP19 sequence, which is useful when post-translational modifications or splice variants may alter individual binding sites. Typical experimental use involves resolving whole-cell lysates by SDS-PAGE, transferring to a nitrocellulose or PVDF membrane, and probing at working dilutions appropriate to the user's chemiluminescent or chromogenic detection system.

For storage stability, the antibody should be aliquoted upon arrival and stored frozen at -20°C; repeated freeze-thaw cycles should be avoided, and the vial should be kept protected from light when not in use. DUSP19 has been studied in the context of JNK pathway modulation, cellular stress responses, and phosphatase biology, supporting investigations of signaling cascades and dual-specificity phosphatase function in cell-based models.