Anti-DTNBP1 Antibody

This rabbit polyclonal antibody targets DTNBP1 (dystrobrevin binding protein 1), the gene product commonly known as dysbindin, a subunit of the BLOC-1 complex that contributes to lysosome-related organelle biogenesis and synaptic vesicle trafficking. Strongly expressed in neurons and concentrated at presynaptic terminals, dysbindin participates in glutamate release and dopaminergic signaling, positioning it as a focus of schizophrenia susceptibility studies and broader neuroscience research.

Validated for Western blot, immunohistochemistry, and immunofluorescence, the reagent detects endogenous protein in human, mouse, and rat samples, enabling workflows that span rodent models and human tissue. It is supplied unconjugated at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as cryoprotectant, in a 100 µl volume that supports repeated blotting and staining experiments. Store at -20 °C and protect from light to preserve activity across multiple uses.

Antibodies.com offers this polyclonal reagent for studies including dysbindin localization in brain sections, BLOC-1 complex assembly, and characterization of synaptic protein changes linked to neuropsychiatric and neurodevelopmental disorders.