Anti-DSG4 Antibody

Desmoglein 4 (DSG4) is a calcium-binding transmembrane glycoprotein belonging to the desmosomal cadherin family, and this rabbit polyclonal reagent from Antibodies.com enables Western Blot detection of the protein in lysates derived from human, mouse, and rat tissues. The antibody is supplied unconjugated at 1 mg/ml in phosphate buffered saline adjusted to approximately pH 7.3, with 0.05% sodium azide included as a preservative, and ships in a 100 µl vial for immunoblotting workflows.

DSG4 functions as a structural component of desmosomes that mediate adhesion between differentiating keratinocytes of the hair-shaft cortex, and pathogenic variants in the gene encoding this protein have been mapped to inherited hair disorders such as monilethrix and localized autosomal recessive hypotrichosis. Researchers therefore apply this antibody in studies of epidermal and hair-follicle differentiation, desmosome assembly, and barrier formation. For handling, refrigerate and protect from light; the sodium azide content precludes live-cell or in vivo applications, so the reagent is restricted to fixed samples, tissue lysates, and other in vitro preparations.