Anti-DSG2 Antibody

The Antibodies.com rabbit polyclonal antibody to DSG2 (Desmoglein-2) is an unconjugated IgG reagent validated for Western Blot detection across human, mouse, and rat samples. Supplied as 50 µl in a vial, the polyclonal antibody binds the desmosomal cadherin DSG2, a calcium-dependent transmembrane glycoprotein that anchors intermediate filaments at desmosomal plaques and mediates strong cell-cell adhesion in epithelia and cardiomyocytes. Researchers apply this reagent to study desmosomal integrity in cardiac tissue, where DSG2 mutations are linked to arrhythmogenic right ventricular cardiomyopathy (ARVC) and disrupted myocyte coupling. Beyond cardiac biology, the antibody is used to investigate epithelial barrier function, desmosome-related skin fragility disorders, and altered DSG2 expression documented in several carcinomas. Aliquot upon receipt and store at -20 °C to limit freeze-thaw cycles and preserve polyclonal activity over extended use.