Anti-DPYSL5 Antibody [Assigned #A2878]

A mouse monoclonal IgG reagent from Antibodies.com that recognizes dihydropyrimidinase-like 5 (DPYSL5), the 564-residue cytoskeletal regulator also known as collapsin response mediator protein 5 (CRMP5). The unconjugated format is supplied as a 200 µl vial and is specified for western blot and immunofluorescence work across human, mouse, and rat samples, enabling side-by-side comparison of orthologous expression and supporting studies of neurite outgrowth, axon guidance, and dendritic development in neural development or injury models.

DPYSL5/CRMP5 is an intracellular phosphoprotein highly expressed in adult central and peripheral neurons and has been linked to Ritscher-Schinzel syndrome type 4 (RTSC4), in which loss-of-function variants disrupt the normal interaction of DPYSL5 with the cytoskeletal partners MAP2 and TUBB3. Because the antibody is unconjugated, it can be paired with a fluorescently labeled or enzyme-conjugated secondary reagent selected for the laboratory's imaging or blotting platform; researchers studying CRMP5-IgG seropositivity in paraneoplastic neurological syndromes linked to small-cell lung carcinoma and thymoma also use such clones to confirm antigen recognition on transfected cells and on tissue sections. Each vial is intended for research use only and should be titrated alongside appropriate positive and negative controls under local experimental conditions.