Anti-DPYD Antibody

Raised in rabbit against dihydropyrimidine dehydrogenase, this polyclonal primary antibody from Antibodies.com targets the rate-limiting enzyme of the pyrimidine catabolism pathway. The unconjugated reagent is supplied as a 100 µl volume in a vial format suitable for both Western Blot (WB) and Immunohistochemistry (IHC) workflows, and has been validated on Human, Mouse, and Rat samples.

DPYD is best known for its role in clearing 5-fluorouracil and related fluoropyrimidine chemotherapeutics, and translational laboratories apply this antibody to profile enzyme expression in colorectal, gastric, and breast tumor biopsies. Researchers also use it to study DPYD polymorphisms linked to severe fluoropyrimidine toxicity and to investigate DPYD deficiency, a rare inborn error of pyrimidine metabolism. Aliquot on receipt and refrigerate to preserve polyclonal activity; protect from light and avoid repeated freeze-thaw cycles.