Anti-DPYD Antibody

DPYD (Dihydropyrimidine Dehydrogenase) is the rate-limiting enzyme in the catabolism of pyrimidine bases and is clinically significant for its role in 5-fluorouracil metabolism, where genetic polymorphisms influence chemotherapeutic response and toxicity in oncology patients. This Rabbit polyclonal antibody from Antibodies.com targets the DPYD protein and is validated for Western blot and immunohistochemistry applications across Human, Mouse, and Rat samples, making it a practical tool for both basic research into nucleotide metabolism and translational studies of fluoropyrimidine response. The reagent is supplied as 100 µL of unconjugated antibody at 1 mg/ml in Phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2, a formulation suited to standard laboratory protocols and recommended for storage at -20 °C in small aliquots to preserve activity and limit freeze-thaw cycles. Researchers studying dihydropyrimidine dehydrogenase expression, thymine-uraciluria, or 5-FU pharmacogenomics will find this polyclonal reagent well matched to detection of the native protein in tissue sections and lysates, supporting work ranging from pathway biochemistry to patient stratification studies.