Anti-DOK4 Antibody

The DOK4 (Docking Protein 4) polyclonal antibody from Antibodies.com is a rabbit-hosted reagent targeting the DOK4 adaptor protein. Supplied as 100 µl of unconjugated polyclonal antiserum, the antibody supports detection of endogenous DOK4 across human, mouse, and rat samples using western blot, immunohistochemistry, and immunofluorescence protocols commonly adopted in cell signaling and neuroscience laboratories.

DOK4 is a member of the DOK family of phosphotyrosine-binding adaptor proteins that operate downstream of receptor tyrosine kinases such as RET, contributing to growth factor and neurotrophic signaling cascades. Research groups investigating these pathways use this reagent to map DOK4 distribution in transfected cell lines, primary neuronal cultures, and fixed tissue sections. The unconjugated format allows flexible pairing with custom fluorophore or enzyme conjugates, giving laboratories freedom to select detection chemistry tailored to each experimental design.

Each vial arrives ready for refrigerated benchtop storage and routine aliquoting before long-term freezing to minimize freeze-thaw exposure. Researchers commonly apply the antibody to validate DOK4 expression in cellular and tissue model systems where the adaptor has been implicated in downstream kinase recruitment and cytoskeletal organization studies. Its polyclonal nature provides multiple epitope coverage, which can be useful when probing low-abundance adaptor pools or when DOK4 is examined alongside related DOK-family members in comparative signaling experiments.