Anti-Dok-5 Antibody

Dok-5 is a 306-amino-acid adaptor protein belonging to the Dok family of downstream-of-kinase signaling molecules, expressed predominantly in neuronal tissues where it interacts with TrkB and Ret receptor tyrosine kinases to promote neurite outgrowth and downstream MAPK and PI3K signaling cascades.

This unconjugated polyclonal reagent from Antibodies.com targets the Dok5 protein and is validated for western blot and ELISA workflows. With confirmed reactivity against human and mouse samples, it supports studies of receptor tyrosine kinase signaling, neurotrophic factor pathways, and nervous system development. Each vial contains 100 µl of antibody, supplied as a polyclonal preparation raised in rabbit.

For applications including immunoblotting of cell lysates and tissue homogenates, the antibody serves as a specific probe for endogenous Dok5 levels. Storage recommendations include refrigerated handling and aliquoting to minimize freeze-thaw cycles when the reagent is used across multiple experiments. Researchers investigating downstream effectors of NGF or BDNF pathways, or screening for alterations in Dok5 expression in neurological disease models, will find this tool applicable to standard immunodetection protocols.