Anti-DOCK 180 Antibody

Primary antibodies raised against DOCK 180 (Dedicator of Cytokinesis 1, DOCK1) from Antibodies.com are affinity-purified rabbit polyclonal reagents supporting research into Rac-mediated cytoskeletal remodeling. DOCK 180 acts as a guanine nucleotide exchange factor for Rac1, driving lamellipodia formation, integrin-mediated adhesion, phagocytic cup assembly, and directed cell migration downstream of engulfment and chemotaxis signaling. Aberrant DOCK 180 expression has been documented in invasive carcinomas, glioblastoma, and immune-cell migration studies, making the target relevant to oncology, neurobiology, and immunology workflows.

This unconjugated polyclonal antibody recognizes the human DOCK 180 protein and is supplied as a 100 µl liquid aliquot in a single-use vial. Recommended applications include western blot, immunohistochemistry, and immunofluorescence staining on fixed cells and cryosectioned tissue. The reagent was raised in rabbit and validated on human samples; species cross-reactivity data is available from Antibodies.com on request. For routine handling, store the vial at -20 °C in working aliquots to limit freeze-thaw cycles, centrifuge briefly before opening, and protect from light. For research use only; not intended for diagnostic or therapeutic use.