Anti-DNMT3B Antibody

This rabbit polyclonal antibody from Antibodies.com targets DNMT3B, the DNA methyltransferase 3B enzyme responsible for establishing de novo methylation patterns at CpG dinucleotides during mammalian development.

DNMT3B contributes to genomic imprinting, X-chromosome inactivation, and silencing of endogenous retrotransposons. Loss-of-function mutations in DNMT3B underlie ICF syndrome, a rare immunodeficiency disorder characterized by centromeric instability and facial anomalies, making this reagent useful for studies of epigenetic regulation, chromatin biology, and disease mechanisms. In oncology, aberrant DNMT3B expression has been documented across multiple tumor types, supporting its relevance to cancer epigenetics research.

The reagent is supplied as 100 µl of unconjugated antiserum raised in rabbit and validated for Western blot, immunohistochemistry, and immunofluorescence workflows on human samples. Aliquot upon arrival and store at -20 °C to preserve reactivity; avoid repeated freeze-thaw cycles to maintain performance across multiple experiments.