Anti-Dnmt3b Antibody

This rabbit polyclonal antibody from Antibodies.com targets human Dnmt3b (DNA methyltransferase 3B), the catalytic enzyme responsible for de novo CpG dinucleotide methylation during early embryonic development. Unconjugated and validated across western blot, immunohistochemistry, immunofluorescence, and ELISA workflows, it serves as a versatile reagent for epigenetics labs studying X-chromosome inactivation, genomic imprinting, and tumor methylation landscapes.

Dnmt3b is best known as the gene mutated in ICF syndrome (immunodeficiency, centromeric instability, facial anomalies) and is frequently upregulated across multiple tumor types. Researchers working on nuclear reprogramming, pluripotency, or cancer epigenetics rely on robust anti-Dnmt3b detection to map methylation dynamics in cell culture models and in vivo tissue sections. Because the reagent is unconjugated and polyclonal, it can be paired with secondary antibodies of the researcher's choice (HRP, biotin, Alexa Fluor, and similar) for flexible detection chemistries.

Each vial contains 100 µl of liquid antiserum. Centrifuge briefly before opening; aliquot to limit freeze-thaw cycles and protect from light when stored at -20 °C in working aliquots.