Anti-DNMT3B Antibody

This rabbit polyclonal antibody from Antibodies.com targets DNMT3B (DNA methyltransferase 3B), a de novo methyltransferase that establishes 5-methylcytosine marks on DNA during early development and in somatic tissues. The unconjugated reagent is supplied as 100µL at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, validated for Western blot and immunohistochemistry workflows on human samples.

DNMT3B is widely studied in epigenetics, X-inactivation, genomic imprinting, and cancer biology, where aberrant methylation contributes to tumor suppressor silencing. Researchers use this reagent to probe expression patterns in cell lines, primary tissues, and archival material, supporting studies on chromatin regulation and developmental gene control.

Store the vial at 4°C for short-term use; for longer-term storage, aliquot and freeze at -20°C to preserve activity across multiple freeze-thaw cycles. Protect from light and handle with appropriate laboratory safety practices given the sodium azide preservative.