Anti-DNMT3B Antibody

Raised in rabbit against human DNMT3B, this polyclonal IgG reagent enables detection of a key de novo DNA methyltransferase across western blot, immunohistochemistry, and immunofluorescence workflows. The unconjugated antibody is supplied as a 100 µl vial by Antibodies.com and is validated for reactivity with human, mouse, and rat samples.

DNMT3B establishes CpG methylation patterns during early embryonic development, X-chromosome inactivation, and genomic imprinting. Loss-of-function mutations in DNMT3B cause ICF syndrome, while overexpression and dysregulation are documented in multiple cancer types, making this antibody a relevant tool for epigenetics, developmental biology, and oncology research programs focused on chromatin remodeling and gene regulation.

To preserve binding activity, store refrigerated and protect from light; aliquot upon arrival to minimize repeated freeze-thaw cycles and maintain a consistent titer for downstream applications in long-term chromatin and gene regulation studies.