Anti-DNMT3A Antibody [Assigned #A10844]

The rabbit monoclonal antibody targeting DNMT3A (DNA methyltransferase 3A) from Antibodies.com supports research into de novo DNA methylation, an epigenetic mechanism that establishes methylation patterns during embryonic development, cellular differentiation, and gene silencing. DNMT3A is a key enzyme in setting up tissue-specific methylation marks, and its recurrent mutation in acute myeloid leukemia and related hematological malignancies makes this reagent valuable for studies in cancer epigenetics, hematopoiesis, and developmental biology.

Supplied as a 50µl aliquot of unconjugated IgG (clone A10844), the antibody is validated for Western Blot and Immunofluorescence workflows and has been confirmed reactive against human, mouse, and rat samples. Researchers commonly apply it to assess DNMT3A expression levels, subcellular localization, and dynamic changes in response to experimental perturbations of the epigenetic landscape, including gene knockout studies, pharmacological inhibition assays, and differentiation time-course experiments.

For long-term stability, store frozen at -20°C, protect from light, and aliquot upon receipt to limit freeze-thaw cycles. Intended for research use only.