Anti-DNMT3A Antibody [Assigned #A10844]

DNMT3A (DNA methyltransferase 3 alpha) is a de novo methyltransferase that establishes CpG methylation patterns during embryonic development and is recurrently mutated in acute myeloid leukemia and other hematologic malignancies. This unconjugated Rabbit IgG monoclonal reagent from Antibodies.com targets the catalytic C-terminal domain of human DNMT3A and cross-reacts with mouse and rat orthologs, supporting cross-species studies of epigenetic regulation. The antibody is supplied as a 200 µl liquid aliquot in a single-use vial and is validated for western blot detection of endogenous DNMT3A in whole-cell lysates as well as immunofluorescence localization in fixed cells. Detailed immunogen epitope information, recommended working dilutions, and validated positive-control lysates are documented on the manufacturer's product datasheet. Store aliquots frozen at -20 °C in working volumes to limit freeze-thaw cycles and protect from light; for short-term use, keep refrigerated. Provided by Antibodies.com as a research-use-only reagent for chromatin biology and cancer epigenetics laboratories.