Anti-DNMT3A Antibody

This rabbit polyclonal reagent targets DNA (cytosine-5)-methyltransferase 3A (DNMT3A), the de novo methyltransferase responsible for establishing DNA methylation marks during embryogenesis, gametogenesis, and X-chromosome inactivation. Raised in rabbit and supplied by Antibodies.com as an unconjugated IgG preparation in a 200µl volume, this reagent supports Western blot and immunofluorescence workflows in human and rat sample panels. Researchers studying epigenetic regulation, acute myeloid leukemia biology, and Tatton-Brown-Rahman syndrome commonly use DNMT3A-specific reagents to map methyltransferase activity in transformed cell lines and primary tissues. The polyclonal format offers broader epitope coverage for detecting endogenous DNMT3A isoforms, which is useful when probing post-translational modifications or isoform switching events. Store undiluted aliquots refrigerated at 4 degrees C, protected from light, and avoid repeated freeze-thaw cycles to preserve binding activity across downstream blotting and microscopy applications.