Anti-DNMT3A Antibody

This polyclonal antibody targets DNMT3A (DNA methyltransferase 3A), a key enzyme responsible for establishing de novo DNA methylation patterns during embryonic development and cellular differentiation. DNMT3A is widely studied in epigenetics research, where it is implicated in gene silencing, X-inactivation, genomic imprinting, and tumor suppressor regulation. Recurrent mutations in DNMT3A are frequently detected in acute myeloid leukemia and other hematological malignancies, making it a relevant target in cancer biology.

Raised in rabbit and supplied as an IgG polyclonal reagent at 100 µl, this unconjugated antibody is validated for Western blot and immunofluorescence workflows. It has been tested for reactivity against human and rat samples, supporting studies in mammalian cell lines, primary tissues, and rodent disease models. Compatible with standard immunolabeling protocols, it allows researchers to monitor DNMT3A protein expression and subcellular localization in fixed cells and tissue sections.

From Antibodies.com, the reagent is provided in a research use only format for chromatin and methylation studies. Storage at -20°C with aliquoting helps preserve antibody activity across multiple freeze-thaw cycles. Researchers commonly apply it to investigate DNA methylation dynamics, stem cell reprogramming, and oncogenic pathways driven by epigenetic dysregulation.