Anti-DNMT3A Antibody

Offered through the Antibodies.com catalogue, this affinity-purified reagent is a rabbit polyclonal antibody raised against DNMT3A (DNA cytosine-5-methyltransferase 3A), the de novo methyltransferase implicated in embryonic development, hematopoiesis and recurrently mutated in adult acute myeloid leukemia. The immunogen is a recombinant human DNMT3A protein, and the antibody recognizes endogenous levels of total DNMT3A in lysate-based assays. It is supplied as an unconjugated preparation at 1.0 mg/mL in 50 µL of phosphate-buffered saline (pH 7.4) containing 150 mM NaCl, 0.02% sodium azide and 50% glycerol. Host species is rabbit, clonality is polyclonal, and the conjugate label is unconjugated, making it well suited to standard western blot workflows and to downstream detection with anti-rabbit secondary reagents. The supplier has validated reactivity in human samples, with additional cross-reactivity to rat reported on the product sheet. The reagent is shipped at 4 °C and should be aliquoted and stored at -20 °C upon arrival; repeated freeze/thaw cycles should be avoided to preserve antibody activity. For research use only, this Anti-DNMT3A Antibody from Antibodies.com provides a robust, well-characterized tool for epigenetic and chromatin research, methylation studies, and investigations into DNMT3A-driven disease mechanisms.