Anti-DNMT3A Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com targets DNMT3A, a DNA methyltransferase responsible for de novo CpG methylation during development and in hematopoietic lineages. The reagent is supplied as 100 µl in a single vial and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

Investigators apply this reagent to study DNMT3A function in epigenetic regulation, acute myeloid leukemia pathogenesis, Tatton-Brown-Rahman syndrome models, and clonal hematopoiesis of indeterminate potential. For long-term storage, aliquot upon receipt and store at -20 °C; avoid repeated freeze-thaw cycles to preserve antibody activity. Short-term use at 4 °C is acceptable for working dilutions.

Affinity-purified from rabbit host serum, the polyclonal preparation recognizes multiple epitopes on the DNMT3A protein, supporting consistent detection in chromatin immunoprecipitation, gene expression studies, and methylation-focused assays. Each lot is screened for performance in WB, IHC, and IF to confirm species reactivity before release.