Anti-DNMT3A Antibody

Antibodies.com provides this rabbit polyclonal antibody targeting DNMT3A, a DNA methyltransferase responsible for establishing de novo CpG methylation patterns during mammalian development and frequently disrupted in acute myeloid leukemia. The unconjugated reagent is supplied in a 100 µl vial of polyclonal antiserum and has been validated for western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows across human, mouse, and rat samples.

Investigators working in cancer epigenetics, chromatin biology, and developmental gene regulation use this reagent to examine DNMT3A expression, study loss-of-function mutations linked to Tatton-Brown-Rahman syndrome, and probe mechanisms behind genomic imprinting and X-chromosome inactivation. Its polyclonal nature delivers broader epitope recognition than monoclonal alternatives, an advantage when analyzing post-translationally modified forms or truncated isoforms of the enzyme.

The antibody supports both routine expression profiling and chromatin immunoprecipitation experiments in basic and translational research laboratories focused on hematological malignancies, neuronal differentiation, and epigenetic reprogramming.