Anti-DNMT3A Antibody

DNMT3A (DNA methyltransferase 3A) is a key de novo methyltransferase that establishes genomic methylation marks during development and cellular differentiation. This recombinant rabbit monoclonal antibody from Antibodies.com targets DNMT3A and is validated for Western blot and immunocytochemistry/immunofluorescence workflows. The unconjugated reagent is supplied as 100 µl of antibody in a buffered solution containing 1× TBS at pH 7.4, 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative. The antibody shows reactivity with human and rat samples, supporting cross-species epigenetic studies relevant to cancer biology, where DNMT3A mutations are frequently observed in acute myeloid leukemia and other hematological malignancies. For handling, store at -20 °C and aliquot upon arrival to preserve activity; avoid repeated freeze-thaw cycles. The monoclonal format provides batch-to-batch consistency for reproducible detection of endogenous DNMT3A protein expression in cell culture and tissue-derived samples.