Anti-DNMT3A Antibody

DNMT3A is a key mammalian de novo DNA methyltransferase that establishes methylation marks at CpG dinucleotides during early development and in adult tissues, with a well-documented role in hematopoietic differentiation and recurrent mutation in acute myeloid leukemia research. This unconjugated polyclonal reagent from Antibodies.com is raised in rabbit and validated for Western blot detection of endogenous DNMT3A in lysates prepared from human, mouse, and rat samples. It is supplied at 1 mg/ml in phosphate buffered saline containing 15 mM sodium azide at approximately pH 7.2, in a 100 µl volume. The antibody is unconjugated, allowing flexibility to pair it with HRP- or fluorophore-labeled secondary reagents according to the user's detection chemistry, and is intended for research use only in studies of epigenetic gene regulation, genomic imprinting, X-inactivation, and cancer biology. Sodium azide is included as a preservative, so the reagent should be handled with appropriate laboratory precautions and is suitable for short-term blotting workflows across multiple gels and membranes.