Anti-Dnmt1 Antibody

This polyclonal reagent from Antibodies.com targets DNA (cytosine-5)-methyltransferase 1, the maintenance methyltransferase responsible for copying CpG methylation patterns onto daughter strands during DNA replication. The unconjugated rabbit antibody is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant, validated for Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation workflows. Cross-reactivity has been confirmed against human, mouse, and rat samples, supporting comparative studies of epigenetic regulation in cancer cell lines, embryonic stem cells, and primary tissue. Each vial contains 100 µl; aliquot on arrival to limit freeze-thaw cycles and store short term at 4°C. Researchers apply this reagent to investigate maintenance methylation, X-inactivation, imprinting control, and DNMT1 deregulation in tumor biology.