Anti-DNM1 Antibody

Dynamin-1 (DNM1) is a ~96 kDa GTPase of the dynamin superfamily that drives membrane fission during clathrin-mediated endocytosis, most prominently at synaptic terminals where it powers vesicle recycling after neurotransmitter release. This rabbit polyclonal IgG reagent from Antibodies.com is raised against DNM1 and validated for Western blot (WB) and immunofluorescence (IF) workflows on human and mouse samples. The unconjugated format leaves the choice of secondary label to the investigator, and the 50 µL vial size supports multiple experiments at common working dilutions. DNM1 is broadly studied in neuroscience for synaptic vesicle turnover, in membrane-trafficking research where dynamin family members act as pinchases for budding vesicles, and in disease models linking DNM1 mutations to developmental and epileptic encephalopathy. Researchers investigating neuronal endocytosis, synaptic plasticity, or DNM1-related neurodevelopmental disorders can use this antibody to detect the endogenous protein in cell and tissue preparations, with the polyclonal format providing tolerance for minor sequence variation between species and isoforms.