Anti-DNER Antibody

DNER (Delta/Notch-like EGF repeat-containing transmembrane protein) is a single-pass transmembrane molecule highly expressed in cerebellar Purkinje neurons, where it mediates neuron-glia communication through the Notch signaling cascade. This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at pH 7.2, and has been validated for western blot detection of the human, mouse, and rat orthologues of the target. Investigators working on Bergmann glia maturation, cerebellar circuit formation, and Notch-related cell-fate decisions use this reagent to probe DNER expression in neuronal and glial lysates. The polyclonal format recognizes multiple epitopes on the target, supporting robust signal across immunoblot membranes. Shipped as a 100 µl vial, the reagent is sufficient for multiple blots. For handling, store refrigerated in the supplied buffer, aliquot to limit freeze-thaw cycles, and protect from light to preserve antibody activity over its shelf life.