Anti-DNAJB11 Antibody

DNAJB11 is an endoplasmic reticulum-resident J-domain co-chaperone that partners with BiP/HSPA5 to drive protein folding and quality control within the secretory pathway. This unconjugated rabbit polyclonal reagent, supplied by Antibodies.com as a 100 µl liquid aliquot, is raised against the human target and has been validated in western blot and immunohistochemistry workflows. Reactivity has been confirmed against human, mouse, and rat samples, supporting cross-species studies of ER chaperone biology in cell lines and tissue sections. Loss-of-function variants in DNAJB11 have been linked to autosomal dominant polycystic kidney disease and a related tubulointerstitial kidney phenotype, so a well-characterized detection antibody is valuable for laboratories working on cystic kidney disease, the unfolded protein response, and ER-associated degradation. The polyclonal format recognizes multiple epitopes on DNAJB11, which is advantageous when probing endogenous expression across different tissues and primary cells, and the unconjugated preparation allows researchers to couple it to their preferred reporter or bead system for immunoblotting, immunoprecipitation, or chromogenic tissue staining.