Anti-DNAJB1 Antibody

DNAJB1 belongs to the Hsp40 (J-protein) family of co-chaperones and partners with Hsp70 machinery to drive ATP-dependent protein folding, refolding of misfolded substrates, and triage of aggregation-prone clients during cellular stress. This rabbit polyclonal reagent from Antibodies.com targets an epitope within DNAJB1 and supports researchers investigating chaperone networks, proteostasis, and stress-granule biology in neuronal and non-neuronal systems.

The antibody is unconjugated and supplied as 100 µL of ready-to-use stock, often aliquoted for repeated assays to limit freeze-thaw cycles. It has been validated across Western blot to confirm expected band patterns, immunohistochemistry to map tissue distribution of DNAJB1 in paraffin or frozen sections, and immunofluorescence to visualize subcellular localization under basal and stress-induced conditions.

Reactivity is reported for Human, Mouse, and Rat samples, making the reagent broadly useful for comparative studies spanning human disease models and rodent knock-out or knock-in systems. Laboratories studying neurodegeneration, polyglutamine-expansion disorders, heat shock responses, and protein quality control frequently deploy this antibody alongside Hsp70-family markers to dissect co-chaperone recruitment and substrate handover in vitro and in vivo research use only workflows.