Anti-DnaJ homolog subfamily B member 1 Antibody

Rabbit polyclonal antibody targeting DnaJ homolog subfamily B member 1, supplied by Antibodies.com as a 100 µg aliquot for Western blot and immunohistochemistry applications. This unconjugated primary antibody was raised in rabbit and validated for reactivity with human samples. DNAJB1, also known as Hsp40, functions as a J-domain co-chaperone that partners with Hsp70 family members to facilitate nascent protein folding, refold stress-denatured substrates, and triage misfolded polypeptides through cellular quality-control pathways.

Researchers studying heat shock responses, proteostasis networks, and chaperone biology rely on DNAJB1 detection to map stress-induced expression changes across cell and tissue models. The reagent also supports investigations into neurodegenerative disease research, where dysregulated Hsp40/Hsp70 activity contributes to protein aggregation pathology, and into oncology workflows, where altered DNAJB1 levels have been reported in specific tumor types. Provided as 100 µg of unconjugated antiserum, the antibody is suitable for standard immunoblotting protocols and tissue section staining workflows in human-derived specimens.