Anti-DNA pol delta cat Antibody

This unconjugated rabbit polyclonal antibody targets the catalytic subunit of human DNA polymerase delta (POLD1), the replicative enzyme responsible for lagging-strand synthesis during S phase. Raised in rabbits and supplied by Antibodies.com as 100 µl per vial, the reagent is validated for western blot and immunofluorescence workflows on human samples. Because the antibody is unconjugated and polyclonal, it offers flexibility for direct-labeling and secondary-reagent detection schemes in both fixed-cell and lysate-based assays.

DNA polymerase delta functions through coordinated polymerase and 3' to 5' proofreading exonuclease activities, contributing to Okazaki fragment maturation, mismatch repair, and homologous recombination. POLD1 expression is tightly coupled to proliferative state, which makes anti-POLD1 reagents useful markers in studies of replication stress, genomic instability, oncogenesis, and cell-cycle entry in human cell models.